Zopiclone is a cyclopyrrolone derivative with hypnotic and sedative actions, anticonvulsant and muscle relaxant properties similar to benzodiazepines.
It binds to a site in the GABA-A-benzodiazepine-chloride channel macromolecular-receptor complex, which is different from that of the benzodiazepine binding site.
Used as hypnotic and sedative.
Indication: short-term management of insomnia
Adult, PO: 7.5 mg at bedtime.
Elderly, PO: initially, 3.75 mg at bedtime.
Hepatic impairment. Mild to moderate: initially 3.75 mg at bedtime. Severe: contraindicated.
Adverse drug reactions
: metallic or bitter aftertaste; irritability, confusion, depressed mood, aggressiveness, incoordination, anterograde amnesia, drowsiness, lightheadedness, nausea, vomiting, urticaria, rashes.
See reference for details.
Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.