Adult
PO
Allergic and inflammatory responses 4-48 mg/day.
Mouth ulceration - as 0.1% paste: apply about 0.6 cm 2-3 times/day. Re-evaluate if recovery does not occur after 7 days.

IM
Allergic and inflammatory responses - as acetonide: 20-80 mg.; as diacetate: 40 mg.
Hay fever - as acetonide: 40-100 mg.; - as diacetate: 40 mg/wk.
Intra-articular inflammatory joint disease - as acetonide: smaller joints: 2.5-5 mg (up to 10 mg), larger joints: 5-15 mg (up to 40 mg). Max: 20-80 mg/treatment. - as hexacetonide: initial: 2-20 mg/day.

Intradermal
Inflammatory skin conditions - as acetonide: 1-3 mg/site. Max: 30 mg in total if several sites of inj used; -as diacetate: 5 mg in divided doses for small lesions, up to 48 mg in divided doses for large lesions. Max: 12.5 mg/inj site. Max: 25 mg/lesion. - as hexacetonide: Max: 80 mcg/cm2 of affected skin.

Topical
Inflammatory skin conditions - as acetonide: as 0.025-0.5% cream/lotion/oint: apply 2-3 times/day.

Adverse drug reactions: HPA axis suppression, intracranial hypertension, Cushing's syndrome, growth retardation in children; osteoporosis, fractures. Peptic ulceration; glaucoma; hyperglycaemia; GI upsets; increased appetite; increased fragility of skin; behavioural changes. Topical: systemic absorption if applied to large areas, broken skin or under occlusive dressing.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.