Sumatriptan is a selective serotonin agonist that acts at 5-HT1 receptors. It causes vasoconstriction of cranial arteries and/or inhibition of neurogenic inflammatory processes in the central nervous system. A small but significant delay in gastric emptying also occurs.

Adult
PO
Migraine >18 yr: 50-100 mg, repeat 2 hrly if migraine recurs. Max: 300 mg/24 hr.

SC
Migraine cluster headache >18 yr: 6 mg as a single dose, repeat at least 1 hr after the 1st dose if needed. Max: 12 mg/24 hr.

Nasal
Migraine 12-17 yr: 10 mg into 1 nostril, max: 20 mg/24 hr; >18 yr: 20 mg into 1 nostril, max: 40 mg/24 hr. May repeat dose at least 2 hr after the 1st dose if needed.

Adverse drug reactions: transient hypertension, hypotension, dizziness, flushing, fatigue, drowsiness, weakness, seizures, nausea and vomiting, rebound headache with frequent use.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.