Edema. Initial: 100 mg/day, may adjust dose according to response up to 400 mg/day.
Hepatic cirrhosis w/ ascites and edema. Depending on urinary Na/K ratio: If >1: Initial: 100 mg/day; if <1: Initial: 200-400 mg/day.
Diagnosis of primary hyperaldosteronism. Long test: 400 mg/day for 3-4 wk. Short test: 400 mg/day for 4 days.
Pre-op management of hyperaldosteronism: 100-400 mg/day. Long-term maintenance in the absence of surgery: Admin the lowest effective dose.
HTN, as monotherapy. Initial: 50-100 mg in 1-2 divided doses, may adjust dose after 2 wk.
Severe CHF as adjunct. Initial: 25 mg once daily to max 50 mg/day. May reduce to 25 mg every other day if 25 mg once daily dose is not tolerated.
Diuretic-induced hypokalemia: 25-100 mg/day.
Adverse drug reactions
: drowsiness, dizziness, headache, lethargy, leg cramps, GI disturbances, ataxia, mental confusion, rashes, pruritus, alopecia, hyponatremia, electrolyte disturbances, gynecomastia, hirsutism, menstrual irregularities, breast pain, transient elevation in BUN concentration.
Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.