What is Sertraline hydrochloride - Meaning and definition

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: February 19, 2019.

The hydrochloride salt of sertraline, a synthetic derivative of naphthalenamine with anti-serotoninergic and antidepressant properties.
Sertraline appears to selectively inhibit the neuronal uptake of serotonin, raising serotonin levels in the CNS.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: February 19, 2019.

Adult
PO
Depression, obsessive-compulsive disorder. Initial: 50 mg/day, may increase in increments of 50 mg at wkly intervals. Max: 200 mg/day.
Panic disorder, post-traumatic stress disorder, social anxiety disorder. Initial: 25 mg/day, increased to 50 mg/day after a wk. May increase in increments of 50 mg at wkly intervals. Max: 200 mg/day.
Premenstrual dysphoric disorder. Initial: 50 mg/day. May increase in increments of 50 mg per menstrual cycle. Max: 150 mg/day (for continuous dosing) or 100 mg/day (during luteal phase). Patient who requires 100 mg/day during luteal phase-only: Initial: 50 mg/day for the first 3 days of each luteal phase period.

Adverse drug reactions: hepatitis, liver failure, jaundice, pancreatitis, stomatitis, palpitation, HTN, hypercholesterolemia, DM, tachycardia, bronchospasm, postural hypotension, amnesia, paresthesia, aggression, urinary incontinence, tinnitus.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Sertraline hydrochloride

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