5-hydroxytryptamine (5-HT) or serotonin, is a neurotransmitter that it is primarily found in the gastrointestinal (GI) tract, platelets, and in the central nervous system (CNS).
It is implicated in a vast array of physiological and pathophysiological pathways. Receptors for 5-HT mediate both excitatory and inhibitory neurotransmission, and modulate the release of many neurotransmitters including glutamate, GABA, dopamine, epinephrine/norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin and cortisol.
In the CNS, 5-HT receptors can influence various neurological processes, such as aggression, anxiety and appetite, and as a result are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, and anorectics.
The European Bioinformatics Institute (EMBL-EBI). Internet. Accessed on January 28, 2016.