A drug with psychotomimetic (also known as psychotogenic
) actions mimics the symptoms of psychosis, including delusions and/or delirium, as opposed to just hallucinations. Psychotomimesis
is the onset of psychotic symptoms following the administration of such a drug.
Some drugs of the opioid class have psychotomimetic effects. Particularly, mixed kappa receptor agonist mu receptor antagonist opioid analgesics can cause dose-related psychotomimesis. This adverse effect, incidence 1–2%, limits their use. Pentazocine and butorphanol fall under this opioid class.
There is evidence that cannabinoids are psychotomimetic, especially delta-9-tetrahydrocannabinol (THC). Intravenous THC produces effects that resemble schizophrenia in both the positive symptoms (illusions, paranoia, and disorganized thinking) and negative symptoms (apathy, anhedonia, alogia, asociality, avolition).
Some types of cannabis may be more psychotomimetic than others, probably due to the action of cannabidiol (CBD), which inhibits P450 3A11's metabolic conversion of THC to 11-hydroxy-THC, which is four times more psychoactive.
Adapted from Wikipedia, the free encyclopedia. Internet. Accessed on July 13, 2017.