A hypnotic alkylphenol derivative.
Formulated for intravenous induction of sedation and hypnosis during anesthesia, propofol facilitates inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA).
This agent is associated with minimal respiratory depression and has a short half-life with a duration of action of 2 to 10 minutes.
Induction and maintenance of general anesthesia. Induction: 40 mg every 10 sec. Maintenance: 4-12 mg/kg/hr or intermittent boluses of 20-50 mg.
Sedation in diagnostic and surgical procedures. Initial: 6-9 mg/kg/hr by infusion. Maintenance: 1.5-4.5 mg/kg/hr.
For ventilated patients: 0.3-4 mg/kg/hr. Monitor lipid concentrations if duration of sedation >3 days.