What is Prochlorperazine - Meaning and definition

Published by Roberto Wenk. Last updated date: November 26, 2018.

A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistamine, and anticholinergic activities.
Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: January 27, 2019.

Adult
PO
Prevention of nausea and vomiting - maleate or mesilate: 5-10 mg 2-3 times/day.
Nausea and vomiting - maleate or mesilate: 20 mg, may repeat if needed.
Psychoses - maleate or mesilate: 12.5 mg twice daily for 7 days, adjust gradually according to response. Maintenance: 25-50 mg/day.
Adjunctive management of severe anxiety disorders - maleate or mesilate: 5-10 mg up to 3-4 times/day.
Vertigo - maleate or mesilate: 15-30 mg/day in divided doses. May reduce gradually to 5-10 mg/day.

IM
Nausea and vomiting - mesilate: 12.5 mg, may repeat via PO if needed.
Psychoses - mesilate: 12.5-25 mg 2-3 times/day.

Rectal
Nausea and vomiting - 25 mg supp: 1 supp twice daily.
Psychoses - maleate: 25 mg 2-3 times/day.

Adverse drug reactions: cholestatic jaundice, cardiac arrhythmias, orthostatic hypotension, dry mouth, blurring of vision, glaucoma, urinary retention, constipation, galactorrhea, gynecomastia, amenorrhea, impotence.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Prochlorperazine

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