What is Oxycodone hydrochloride - Meaning and definition

Published by Roberto Wenk. Last updated date: June 15, 2016.

The hydrochloride salt of oxycodone, a methylether of oxymorphone and semisynthetic opioid agonist with analgesic and antitussive properties.
Oxycodone binds to mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opiates. In addition to analgesia and a depressive effect on the cough center in the medulla, this agent may cause euphoria, anxiolysis, miosis, sedation, physical dependence, constipation, and respiratory depression, depending on dosage and variations in individual metabolism.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: January 17, 2019.

Adult
PO
Initially, 5 mg 4-6 hrly may increase as necessary. Extended-release tab: 5-10 mg 12 hrly. Max: 400 mg/day.

IV
Injection: 1-10 mg over 1-2 min, repeated not more often than 4 hrly.
Infusion. Initial: 2 mg/hr, increased as necessary. Patient-controlled analgesia (PCA): 0.03 mg/kg, admin w/ a minimum lock-out time of 5 min.

SC
Injection. Initial: 5 mg 4 hrly.
Infusion. Initial: 7.5 mg/day adjusted according to response.

Adverse drug reactions: nausea, constipation, vomiting, respiratory depression, headache, pruritus, insomnia, dizziness, asthenia, somnolence, abdominal pain, chills and fever, hypotension, anorexia, diarrhea, dyspepsia, dysphagia, anxiety, nervousness, tremor, vasodilation, cough, dyspnea, rash.

See also Instructions and conversion table and Opioid dose conversion

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Oxycodone hydrochloride

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