What is Omeprazole - Meaning and definition

Published by Roberto Wenk. Last updated date: February 16, 2016.

A benzimidazole with selective and irreversible proton pump inhibition activity.
Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion.
This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: January 16, 2019.

Adult
PO
Peptic ulcer: 20 or 40 mg/day in severe cases for 4 wk (duodenal ulcer) or 8 wk (gastric ulcer). Maintenance: 10-20 mg/day.
NSAID-associated ulceration: 20 mg/day.
Gastroesophageal reflux disease: 20 mg once daily for 4 wk, may continue for another 4-8 wk if needed.
Gastroesophageal reflux disease oesophagitis: 40 mg/day. Maintenance: 20 mg/day (after healing of oesophagitis); 10 mg/day (acid reflux).
Erosive oesophagitis: 20 mg daily for 4-8 wk. Maintenance: 20 mg/day.
Acid-related dyspepsia: 10 or 20 mg/day 2-4 wk.
Zollinger-Ellison syndrome. Initial: 60 mg once daily. Dose range: 20-120 mg/day. All doses to be given once in the morning but doses >80 mg in 2 divided doses. Prophylaxis of acid aspiration during general anaesthesia: 40 mg in the evening and another 40 mg 2-6 hr pre-op.
H.pylori infection: 20 mg bid or 40 mg once daily with clarithromycin and either amoxicillin or metronidazole.

IV
Gastric and duodenal ulcers; NSAID-associated ulceration; Gastroesophageal reflux disease: 40 mg once daily infused over 20-30 min or slow inj over 5 min until PO can be resumed.
Zollinger-Ellison syndrome. Initial: 60 mg/day, adjust if needed. Daily doses >60 mg/day should be given in 2 divided doses.

Adverse drug reactions: increased risk of clostridium difficile-associated diarrhea and osteoporosis-related fractures. Headache, rash, pruritus, dizziness, fatigue, cough, back or abdominal pain, arthralgia and myalgia, urticaria, dry mouth, bronchospasm, somnolence, insomnia, reversible confusional states, depression, increased liver enzyme, hepatitis, jaundice, hepatic encephalopathy.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Omeprazole

To cite