What is Naproxen - Meaning and definition

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: January 14, 2019.

A propionic acid derivative and a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic, and analgesic activities.
Naproxen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of naproxen. Naproxen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: January 14, 2019.

Adult
PO
Rheumatic disorders: 0.5-1 g/day in 1-2 divided doses.
Acute musculoskeletal disorders; dysmenorrhea. Initial: 500 mg, then 250 mg 6-8 hrly. Max: 1,250 mg on the 1st day and 1,000 mg thereafter.
Acute gout. Initial: 750 mg, then 250 mg 8 hrly.

Adverse drug reactions: peripheral edema, CHF, vasculitis, tachycardia, dyspnea; constipation, heartburn, abdominal pain, nausea; headache, drowsiness, dizziness, vertigo, lightheadedness, inability to concentrate, irritability, fatigue, malaise, insomnia, sleep disorders, dream abnormalities, leucopenia, interstitial nephritis.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

To cite

Naproxen. IAHPC Pallipedia. https://pallipedia.org/naproxen. Accessed