What is Nabilone - Meaning and definition

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: January 14, 2019.

A synthetic cannabinoid and dibenzopyrane derivative with antiemetic activity.
Although the mechanism of action has not been fully elucidated yet, it has been suggested that nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1 and CB2, both of which are coupled to Gi/o proteins.
The CB1 receptors are expressed predominantly in central and peripheral neurons, and receptor stimulation has been implicated in the reduction of chemotherapy-induced nausea.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Last updated date: February 16, 2016.

Nabilone is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It mimics tetrahydrocannabinol (THC), the primary psychoactive compound found naturally occurring in Cannabis.

It is widely used as an adjunct therapy for chronic pain management; numerous trials and case studies have demonstrated modest effectiveness for relieving fibromyalgia and multiple sclerosis.

Adult
PO
1 or 2 mg doses multiple times a day up to a total of 6 mg.

Adverse drug reactions: can increase post-operative pain, dizziness/vertigo, euphoria, drowsiness, dry mouth, ataxia, sleep disturbance, dysphoria, headache, nausea, disorientation, depersonalization, asthenia

Wikipedia, the free encyclopedia. Internet. Accessed on January 18, 2016.

Nabilone

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