Adult
PO
Moderate to severe pain: 5-20 mg, 4 hrly. Extended-release: 5-20 mg 12 hrly.
IV
Pain associated w/ MI: 5-10 mg at 1-2 mg/min followed by a further 5-10 mg as necessary.
Acute pulmonary edema: 5-10 mg via slow injection at 2 mg/min.
Intraspinal
Moderate to severe pain. Initially, 5 mg epidural inj, then 1-2 mg after 1 hr up to a total dose of 10 mg/24 hr, if pain relief is unsatisfactory.
Intrathecal
Moderate to severe pain: 0.2-1 mg once daily, up to 20 mg/day as necessary.
IM/SC
Moderate to severe pain: 5-20 mg
IV
Moderate to severe pain: 2.5-10 mg via slow injection over 4-5 min or a starting dose of 1-2 mg/hr via continuous infusion. Max: 100 mg/day; 4 g/day in cancer patients.
Rectal
Severe pain: 10-20 mg 4 hrly.
Adverse drug reactions: nausea, vomiting, constipation, abdominal pain, dry mouth, anorexia, taste disturbance, dyspepsia, respiratory depression, sedation, dizziness, confusion, insomnia, headache, somnolence, involuntary muscle contractions, hyperhidrosis, rash, pruritus, asthenic conditions, HTN, bronchospasm, seizures, amenorrhea, rhabdomyolysis, nystagmus.
See
Instructions and conversion table and
Opioid dose conversions Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.