Modafinil is a non-amphetamine psychostimulant approved for the treatment of excessive daytime somnolence associated with obstructive sleep apnea, narcolepsy, and shift work sleep disorder.
Narcolepsy, obstructive sleep apnea: 200-400 mg/day as a single dose in the morning or in 2 divided doses.
Shift-work sleep disorder: 200 mg as a single dose 1 hr before starting work.
Adverse drug reactions
: headache, nervousness, insomnia, agitation, confusion, personality disorders, anxiety, hypertension, palpitations, tachycardia, psychosis, depression, mania.
Use in palliative care
: Patients are often seriously debilitated by fatigue, excessive daytime somnolence, and depression, and modafinil may reduce these symptoms.
Modafinil may have a therapeutic niche when methylphenidate use is contraindicated or limited due to side effects.
Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.