Adult
PO
GERD: 10-15 mg 4 times/day. If symptoms are intermittent, may give single doses of 20 mg prior to provoking situation. Max duration: 12 wk.
Diabetic gastric stasis: 10 mg 4 times/day for 2-8 wk.
Nausea and vomiting associated with cancer chemotherapy or radiotherapy: 10 mg, up to tid. Max duration: 5 days.

IM/IV
Diabetic gastric stasis: 10 mg 4 times/day by IM inj or slow IV inj over 1-2 min for up to 10 days. Convert to oral admin when symptoms subside sufficiently.
Prophylaxis of post-op nausea and vomiting: 10 mg as a single dose by IM or slow IV inj over at least 3 min.

IV
Prophylaxis of chemotherapy-induced nausea and vomiting. For highly emetogenic drugs/regimens - Initial: 2 mg/kg by slow inj over at least 15 min, 30 min before chemotherapy. Repeat 2 hrly for 2 doses, then 3 hrly for 3 doses. For less emetogenic drugs/regimens: 1 mg/kg may be used. Max duration: 5 days.
Intubation of the small intestine, premedication for radiologic examination of the upper GI tract: 10 mg as a single dose by slow inj over 1-2 min.

Adverse drug reactions: extrapyramidal symptoms, parkinsonism, drowsiness, anxiety, confusion, GI disturbances, urinary frequency and incontinence, headache.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.