Adult
PO
Anti-inflammatory or immunosuppressive. Initial: 2-60 mg/day, depending on the disease being treated.
Allergic conditions: 24 mg on day 1; 20 mg on day 2; 16 mg on day 3; 12 mg on day 4; 8 mg on day 5; 4 mg on day 6. All doses to be given as a single or in divided doses.

IV
Methyprednisolone Na succinate
Anti-inflammatory or immunosuppressive: 10-500 mg/day.
Acute allograft rejection in organ transplant recipients 0.5-1 g/day.
Status asthmaticus 40 mg, repeated according to patient's response.

IM
Anti-inflammatory or immunosuppressive - methyprednisolone Na succinate: 10-80 mg once daily. - methylprednisolone acetate: 10-80 mg every 1-2 wk.

Intra-articular
Anti-inflammatory or immunosuppressive - methylprednisolone acetate: 4-10 mg (small joints); 10-40 mg (medium joints); 20-80 mg (large joints). May be repeated every 1-5 wk.

Intralesional
Anti-inflammatory or immunosuppressive - methylprednisolone acetate: 20-60 mg every 1-5 wk.
Corticosteroid-responsive dermatoses - methylprednisolone acetate: 20-60 mg, may repeat up to 4 inj at intervals depending on the type of lesion and patient's response to the initial inj.

Topical
Corticosteroid-responsive dermatoses - 0.1% methylprednisolone aceponate ointment, cream or lotion: apply thinly to affected area once daily for up to 12 wk.

Adverse drug reactions: adrenal suppression, anaphylactoid reactions, immunosuppression, acute myopathy, psychiatric disturbances, increased susceptibility and severity of infections, impaired healing, HTN, Na and fluid retention, peptic ulcer, cataract subcapsular, muscular weakness.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.