The citrate salt of the element magnesium with cathartic activity.
The cathartic action of magnesium cations appears to result, in part, from osmotically mediated water retention, which subsequently stimulates peristalsis. In addition, magnesium ions may also stimulate the activity of nitric oxide (NO) synthase and increase the biosynthesis of the phospholipid proinflammatory mediator platelet activating factor (PAF) in the gut. NO may stimulate intestinal secretion via prostglandin- and cyclic GMP-dependent mechanisms while PAF produces significant stimulation of colonic secretion and gastrointestinal motility.
Magnesium citrate is a hyperosmotic saline laxative; it stimulates peristalsis, usually resulting in a bowel movement within 30 minutes to 3 hours.
Adult
PO
Magnesium citrate is given as a liquid by mouth, which can be mixed with water or juice.
Constipation: 240 mL orally one time, followed immediately with a full glass of water.
Adverse drug reactions: loose stools, diarrhea, stomach cramps, upset stomach. Extreme magnesium overdose can result in serious complications: slow heart beat, low blood pressure, drowsiness, etc
