What is Ketoconazole - Meaning and definition

Published by Roberto Wenk. Last updated date: February 17, 2016.

A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity.
Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: January 8, 2019.

Adult
PO
Fungal infections: 200 mg once daily, up to 400 mg once daily if needed.

Topical/cutaneous
Seborrhoeic dermatitis - 2% foam: apply bid for 4 wk. - 1 or 2% shampoo: apply twice wkly for 2-4 wk. Prophylaxis: as 2% shampoo, use once every 1-2 wk.
Pityriasis versicolor; skin fungal infections - 2% cream: apply 1-2 times/day. - 2% shampoo: apply once daily for up to 5 days. Prophylaxis - 2% shampoo: use once daily for up to 3 days before exposure to sunshine.

Adverse drug reactions: adrenal insufficiency; GI disturbances, dermatitis, burning sensation, dizziness, somnolence, fever, photophobia, photosensitivity.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Ketoconazole

Related terms

To cite