Ipratropium bromide causes bronchodilation by blocking the action of acetylcholine at parasympathetic site in bronchial smooth muscle. It also inhibits serous and seromucous gland secretions by nasal application.
COPD, asthma - metered-dose aerosol: 20-40 mcg 3-4 times/day; single doses of up to 80 mcg may be required in some patients. As soln for nebulisation: 250-500 mcg 3-4 times/day.
Rhinorrhea associated w/ rhinitis - metered-dose nasal spray: 42 mcg into each nostril 2-3 times/day, up to 84 mcg into each nostril 3-4 times/day for up to 4 days when rhinorrhea is associated w/ common cold or up to 3 wk when associated w/ seasonal allergic rhinitis.
Adverse drug reactions: dry mouth, constipation, arrhythmias, nausea and vomiting, headaches, dizziness, mydriasis, narrow-angle glaucoma.