What is Indomethacin - Meaning and definition

Published by Roberto Wenk. Last updated date: February 17, 2016.

A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties.
As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines.
This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: January 7, 2019.

Adult
PO
Musculoskeletal and joint disorders. Initial: 25 mg bid or tid. Increase if necessary by 25-50 mg at wkly intervals to 150-200 mg/day.
Acute gout 150-200 mg/day in divided doses.
Dysmenorrhea 75 mg/day.

Rectal
Musculoskeletal and joint disorders - supp: 100 mg inserted at night and repeated in the morning if necessary.

Ophth
Inhibition of intraoperative miosis: 4 drops 1 day pre-op and 4 drops 3 hr pre-op.
Prophylaxis and reduction of post-op ocular inflammation: 1 drop 4-6 times/day.
Post-photorefractive keratectomy pain: 1 drop 4 times/day for a few days post-op.

Adverse drug reactions: CHF, chest pain, arrhythmia, palpitations, HTN, pulmonary HTN, GI disturbances, headache, tinnitus, ataxia, tremor, dizziness, insomnia, vertigo, confusion, psychiatric disturbances.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Indomethacin

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