What is Ibuprofen - Meaning and definition

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: January 7, 2019.

A propionic acid derivative and nonsteroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous injection, ibuprofen inhibits the activity of the enzymes cyclooxygenase I (COX-1) and II (COX-2), resulting in a decreased formation of precursors of prostaglandins and thromboxanes. Inhibition of COX-2 specifically blocks the conversion of arachidonic acid (AA) to prostaglandins, which mediate inflammation, fever, and pain.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: January 7, 2019.

Adult
PO
Rheumatoid arthritis, osteoarthritis: 400-800 mg 3-4 times/day. Max: 3.2 g/day.
Mild to moderate pain; dysmenorrhea; fever: 200-400 mg 4-6 hrly. Max: 1.2 g daily.

IV
Pain relief: 400-800 mg 6 hrly, as needed. Max: 3.2 g/day.
Fever. Initially, 400 mg followed by 400 mg 4-6 hrly, or 100-200 mg 4 hrly. Max: 3.2 g/day.

Topical/cutaneous
Pain and inflammation associated w/ musculoskeletal and joint disorders - 5% cream, foam, gel, spray soln or 10% gel: apply as directed.

Adverse drug reactions: dizziness, headache, nervousness, epigastric pain, heartburn, nausea, decreased appetite, constipation, diarrhea, dyspepsia, flatulence, vomiting, fluid retention, hypernatremia, increased BUN.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Ibuprofen

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