What is Ibandronate sodium - Meaning and definition

Published by Roberto Wenk. Last updated date: February 11, 2016.

The sodium salt of ibadronic acid, a synthetic nitrogen-containing bisphosphonate.
Ibandronic acid inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts.
This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: January 7, 2019.

Adult
PO
Prophylaxis of skeletal events in patients w/ breast cancer and bone metastases: 50 mg/day.
Treatment and prophylaxis of postmenopausal osteoporosis: 150 mg once mthly on the same date each mth, or 2.5 mg/day.

IV
Hypercalcemia of malignancy: 2-4 mg as a single infusion. Max: 6 mg.
Postmenopausal osteoporosis: 3 mg by inj once every 3 mth.
Prophylaxis of skeletal events in patients w/ breast cancer and bone metastases: 6 mg by infusion 3-4 wkly.

Adverse drug reactions: flu-like symptoms (e.g., myalgia, arthralgia, fever, chills, fatigue, nausea, loss of appetite, bone pain), atypical fractures, osteonecrosis of the jaw, ocular inflammation, acute renal failure, hypocalcemia, musculoskeletal pain.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Ibandronate sodium

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