What is Hyoscine - Meaning and definition

Published by Roberto Wenk. Last updated date: June 14, 2016.

Butylscopolamine bromide is an orally available bromide salt form of butylscopolamine, a quaternary ammonium derivative of the alkaloid scopolamine, with anticholinergic property.
Upon oral administration, hyoscine butylbromide binds to and blocks muscarinic receptors located on postganglionic parasympathetic nerve endings and on smooth muscle cells. This blocks the activity of acetylcholine (Ach) and causes its antispasmodic effect in the gastrointestinal (GI), urinary, uterine, and biliary tracts. This agent may also facilitate radiologic visualization of the GI tract.

National Cancer Institute. NCI Drug Dictionary. Internet. January 20, 2016.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: November 28, 2018.

Antimuscarinics/anticholinergics — such as hyoscine hydrobromide, atropine, glycopyrronium/glycopyrrolate, hyoscine butyl bromide — are used primarily as smooth muscle antispasmodics and antisecretory agents.
They are used in palliative care for intestinal colic, genitorurinary colic, inoperable bowel obstruction with colic, and respiratory secretions at end of life.
Hyoscine butylbromide and glycopyrronium/glycopyrrolate are less likely to cross the blood-brain barrier as they are not as lipid-soluble, thereby causing less central side effects (e.g., delirium).
Effective in reducing respiratory secretions at end of life in about one-half to one-third of patients.

Hyoscine hydrobromide
Onset of action: < 10 minutes SC/IM/IV
Plasma ½ life: 5-6 h
Dosing
0.4 mg as a single dose SC
If effective, continue using 0.3-0.6 mg q4h SC

Hyoscine butylbromide
Onset of action: 10 minutes SC/IM/IV. Time to peak plasma concentration: 1-2 h PO

Dosing
20 mg as a single dose SC. If effective, continue, using 20 mg q4h SC

Adverse drug reactions: blurred vision, cardiovascular effects, dry mouth, constipation, heartburn, urinary retention, delirium.

INCTR Palliative Care Handbook. Internet. Accessed on August 21, 2011.

Hyoscine

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