Adrenocortical insufficiency: 20-30 mg/day in 2 divided doses.
Supplement in adrenal insufficiency during surgery under general anesth patients taking >10 mg/day prednisolone or its equivalent by mouth: 25-50 mg at induction.
Minor surgery: resume usual oral dose after surgery
Moderate and major surgery: administer usual oral corticosteroid dose on the morning of the surgery, then IV induction dose,continue w/ similar IV doses 3 times/day for 24 hr after moderate surgery or 48-72 hr after major surgery; resume usual oral dose after inj are stopped.
Acute adrenocortical insufficiency: 100-500 mg 3-4 times/24 hr depending on severity and response.
Soft-tissue inflammation - Na phosphate or Na succinate esters: 100-200 mg as local inj.
Corticosteroid-responsive dermatoses - 0.1-2.5% oint/cream/lotion: apply as directed.
Joint inflammations - acetate: 5-50 mg depending on size of affected joint.
Adverse drug reactions
: sodium and fluid retention, potassium and calcium depletion, muscle wasting, weakness, osteoporosis, GI disturbances and bleeding, increased appetite and delayed wound healing, bruising, hirsutism, raised intracranial pressure, headache, depression, psychosis, menstrual irregularities, yperglycemia, glycosuria, obesity, moon-face, buffalo hump, suppression of pituitary-adrenocortical system.
Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.