What is Hydrocortisone sodium succinate - Meaning and definition

Published by Roberto Wenk. Last updated date: February 11, 2016.

The sodium salt of hydrocortisone succinate with glucocorticoid property.
Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibiting minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes, such as various cytokines and lipocortins.
Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation.

National Cancer Institute. NCI Drug Dictionary. Internet. August 21, 2011.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: November 28, 2018.

Adult
PO
Adrenocortical insufficiency: 20-30 mg/day in 2 divided doses.

IV
Supplement in adrenal insufficiency during surgery under general anesth patients taking >10 mg/day prednisolone or its equivalent by mouth: 25-50 mg at induction.
Minor surgery: resume usual oral dose after surgery
Moderate and major surgery: administer usual oral corticosteroid dose on the morning of the surgery, then IV induction dose,continue w/ similar IV doses 3 times/day for 24 hr after moderate surgery or 48-72 hr after major surgery; resume usual oral dose after inj are stopped.
Acute adrenocortical insufficiency: 100-500 mg 3-4 times/24 hr depending on severity and response.

Inj
Soft-tissue inflammation - Na phosphate or Na succinate esters: 100-200 mg as local inj.

Topical
Corticosteroid-responsive dermatoses - 0.1-2.5% oint/cream/lotion: apply as directed.

Intra-articular
Joint inflammations - acetate: 5-50 mg depending on size of affected joint.

Adverse drug reactions: sodium and fluid retention, potassium and calcium depletion, muscle wasting, weakness, osteoporosis, GI disturbances and bleeding, increased appetite and delayed wound healing, bruising, hirsutism, raised intracranial pressure, headache, depression, psychosis, menstrual irregularities, yperglycemia, glycosuria, obesity, moon-face, buffalo hump, suppression of pituitary-adrenocortical system.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Hydrocortisone sodium succinate

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