What is Glycopyrrolate - Meaning and definition

Published by Roberto Wenk. Last updated date: February 11, 2016.

Glycopyrronium bromide is a medication of the muscarinic anticholinergic group; it blocks muscarinic receptors, thus inhibiting cholinergic transmission.
It does not cross the blood–brain barrier and consequently has no to few central effects. A synthetic quaternary amine, it is available in oral and intravenous (i.v.) forms. The cation, which is the active moiety, is also known as glycopyrrolate.

Wikipedia, the free encyclopedia. Internet. Accessed on January 18, 2016.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: November 21, 2018.

Adult
PO
Peptic ulcer: 1-2 mg 2-3 times/day.

IV
Reversal of neuromuscular blockade: 200 mcg for each 1 mg of neostigmine or 5 mg of pyridostigmine.

IV/IM
Reduction of secretions: Pre-op: 4 mcg/kg via IM administration 30-60 mins before procedure. Intraoperative: 0.1 mg via IV administration, repeat at 2-3 min intervals when needed. Max: 400 mcg/dose.
Peptic ulcer: 0.1-0.2 mg 3-4 times/day.

Adverse drug reactions: xerostomia, loss of taste, nausea, vomiting, constipation, reduced sweating, urinary hesitancy and retention, blurred vision, cycloplegia, increased ocular tension, tachycardia, palpitation, headache, anxiety, bloated feeling, impotence, skin reactions.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Glycopyrrolate

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