Adult
PO
Epilepsy. Initial: 300 mg on the 1st day, 300 mg bid on the 2nd day, and 300 mg tid on the 3rd day; alternatively, 300 mg tid on the 1st day. Dose may increase in increments of 300 mg every 2-3 days until effective anti-epileptic control is achieved, usually w/in 900-3,600 mg/day in 3 divided doses w/ max interval of 12 hr. Max: 4,800 mg/day.
Neuropathic pain. Initial: 300 mg on the 1st day, 300 mg bid on the 2nd day, and 300 mg tid on the 3rd day; alternatively, 900 mg/day in 3 divided doses. Dose may increase in increments of 300 mg every 2-3 days. Max: 3,600 mg/day.
Restless leg syndrome - gabapentin enacarbil, modified-release preparation: moderate to severe: 600 mg once daily at approx 5 pm.
Postherpetic neuralgia - gabapentin enacarbil, modified-release preparation. Initial: 600 mg in the morning for 3 days, then increased to 600 mg bid.

Adverse drug reactions: somnolence/sedation, blood glucose fluctuation, elevated creatine kinase and LFTs, jaundice, fever, hyponatremia, movement disorder, anorexia, increased appetite; depression, anxiety, hostility, confusion and emotional lability, nervousness, abnormal thinking, insomnia, headache, vomiting, nausea, dyspepsia, constipation, diarrhoea, asthenia, pain, malaise, flu syndrome.

CIMS Drug Information System. Internet. Accessed on January 10, 2016.