What is Flurbiprofen - Meaning and definition

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: November 21, 2018.

A derivative of propionic acid, and a phenylalkanoic acid derivative of nonsteroidal anti-inflammatory drugs (NSAIDs) with analgesic, anti-inflammatory and antipyretic effects.
Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation, and fever.
This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Last updated date: February 9, 2016.

Adult
PO
Pain and inflammation: 150-200 mg/day in divided doses. Max: 300 mg/day in acute or severe cases.
Dysmenorrhoea. Initial: 100 mg, then 50-100 mg 4-6 hrly. Max: 300 mg/day.
Sore throat - 8.75 mg loz: dissolve 1 loz 3-6 hrly. Max: 5 loz/day. Max duration: 3 days.

Ophth
Prophylaxis of miosis during ocular surgery - 0.03% soln: instill 1 drop every 30 min starting 2 hr before and ending not less than 30 min before surgery.
Postoperative ocular inflammation - 0.03% soln: instill 1 drop into the eye 4 times/day for 1-3 wk starting at 24 hr after surgery.

Adverse drug reactions: oedema, abdominal pain, constipation, diarrhoea, dyspepsia/heartburn, liver enzyme elevations, flatulence, nausea, vomiting, wt change, headache, nervousness, CNS stimulation or inhibition.

CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Flurbiprofen

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