What is Fluconazole - Meaning and definition

Published by Roberto Wenk. Last updated date: February 9, 2016.

A synthetic triazole with antifungal activity.
Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity.
Mammalian cell demethylation is much less sensitive to fluconazole inhibition.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: November 21, 2018.

Adult
PO
Superficial mucosal candidiasis: 50 mg/day, up to 100 mg/day. Treatment duration: 7-30 days depending on condition.
Candidal balanitis, vag candidiasis: 150 mg as a single dose.
Cutaneous candidiasis, dermatophytosis, pityriasis versicolor: 50 mg once daily for up to 6 wk.
Cryptococcal infections, systemic candidiasis. Initial: 400 mg, then 200-400 mg once daily.
Prevention of relapse after a primary course of treatment for acute cryptococcal meningitis in AIDS patients: 100-200 mg/day.
Prophylaxis of fungal infections in immunocompromised patients 50-400 mg/day.

IV
Cryptococcal infections, systemic candidiasis. Initial: 400 mg, then 200-400 mg once daily.
Prevention of relapse after a primary course of treatment for acute cryptococcal meningitis in AIDS patients: 100-200 mg/day.
Prophylaxis of fungal infections in immunocompromised patients: 50-400 mg/day.

Adverse drug reactions: abdominal pain, diarrhea, flatulence, nausea, vomiting, taste disturbance, headache, dizziness, leucopenia, thrombocytopenia, hyperlipidemia, increased liver enzyme values.

CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Fluconazole

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