What is Cyproheptadine hydrochloride - Meaning and definition

Published by Roberto Wenk. Last updated date: February 8, 2016.

The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties.
Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle.
This agent also competes with free serotonin for binding at serotonin receptor sites.
Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: November 5, 2018.

Adult
PO
Allergic conditions: 4 mg tid. Usual: 12-16 mg/day in 3-4 divided doses. Max: 32 mg/day.
Prevention and treatment of migraine and other vascular headaches: 4 mg, may repeat 30 min later. Not to exceed 8 mg w/in a 4- to 6-hr period. Maintenance: 4 mg 4-6 hrly.

Adverse drug reactions: confusion, disturbed coordination, dizziness, excitation, euphoria, hallucinations, headache, insomnia, irritability, nervousness, restlessness, sedation, seizure, sleepiness, tremor, vertigo, hypotension, palpitation, tachycardia, abdominal pain, anorexia, increased appetite, constipation, diarrhea, nausea, vomiting, hepatitis, hepatic failure, jaundice.

CIMS Drug Information System. Internet. Accessed on January 10, 2016.

To cite

Cyproheptadine hydrochloride. IAHPC Pallipedia. https://pallipedia.org/cyproheptadine-hydrochloride. Accessed