Cyclizine is a sedative antihistamine with antimuscarinic activity.
Belongs to the class of piperazine derivatives used as systemic antihistamines.
Used in the treatment of nausea and vomiting.

Adult
PO
Nausea and vomiting - HCI: 50 mg up to 3 times/day. To be given 30 mins before traveling for prevention of motion sickness.
IV/IM
Motion sickness - lactate: 50 mg 4-6 hrly, to be started 30 mins before traveling.
Post-op nausea and vomiting - lactate: 50 mg up to 3 times/day, to be started 30 mins pre-op. Max: 200 mg/24 hr.

Adverse drug reactions: CNS depression, headache, psychomotor impairment, dry mouth, thickening of mucous secretions, blurred vision, difficult or painful urination, constipation, GI disturbances, palpitations, and arrhythmias.

CIMS Drug Information System. Internet. Accessed on January 10, 2016.