What is Clodronate disodium - Meaning and definition

Published by Roberto Wenk. Last updated date: February 8, 2016.

The disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate.
Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Last updated date: February 8, 2016.

Adult
PO - Osteolytic bone metastases 1.6 g/day. Max: 3.2 g/day.
IV - Hypercalcaemia of malignancy 300 mg/day until normocalcaemia. Treatment duration should not exceed 10 days.

Adverse drug reactions: GI disturbances; musculoskeletal pain; headache; moderate leucopenia; transient proteinuria after IV infusion; electrolyte disturbances; hypersensitivity reactions; local reactions (parenteral); renal impairment (parenteral), bronchospasm.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.

To cite

Clodronate disodium. IAHPC Pallipedia. https://pallipedia.org/clodronate-disodium/. Accessed