An indazole non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-edema properties.
Unlike other NSAIDs, benzydamine hydrochloride does not inhibit cyclooxygenases (COX) but stabilizes membranes, resulting in local anesthesia; inhibits the production of pro-inflammatory cytokines; inhibits the generation of reactive oxygen species by neutrophils; inhibits leukocyte aggregation and adhesion; and exhibits antimicrobial properties.
Painful musculoskeletal and soft tissue disorders: 3-5% cream (as HCl) or 6% cream/spray (as salicylate): apply as directed.
Mouth/throat pain or irritation of the mouth and throat: 0.15% soln (as HCl): gargle 15 mL 1-3 hrly for not >7 days.
Adverse drug reactions: erythema, rash, photosensitivity, numbness or stinging sensation of oral mucosa.