Is a rare syndrome that occurs alone or with other neurologic disorders.
It is usually associated with various cancers; it may occur before or after the diagnosis of cancer.
Patients present a subacute onset of intestinal dysmotility characterized by chronic nausea and anorexia secondary to gastroparesis with delayed gastric emptying, marked small and large intestinal dilatation and poor propulsive activity, and sometimes symptoms and signs consistent with intestinal pseudo-obstruction.
Other manifestations associated with neuropathic and autonomic disorders are: cardiovascular alterations (postural hypotension, syncopal episodes, painless myocardial infarction, and fixed heart rate); pupillary abnormalities; sensory disturbances; and neurogenic bladder.
Ripamonti C and Rodriguez C. Autonomic neuropathy. Topics in palliative care. Volume 1. New York. Oxford University Press. 1997. pp. 75-77.