Antifibrinolytic agents block the binding of plasminogen and plasmin to fibrin, preventing the dissolution of hemostatic plugs. They inhibit the action of plasminogen activators and, to a lesser extent, also have some antiplasmin activity.

Aminocaproic acid
Indication & dosage: treatment and prophylaxis of haemorrhage
Adult
Oral: initially, 4-5 g, followed by 1-1.25 g every hr for about 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr.
Intravenous: initially, 4-5 g as a 2% solution over 1 hr followed by a 1 g/hr infusion continued for up to 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr.
Renal impairment: dosage reduction may be required.

Tranexamic acid
Indication & dosage: short-term management of hemorrhage
Adult
Oral: 1-1.5 g or 15-25 mg/kg bid or tid.
Intravenous: 0.5-1 g or 10 mg/kg tid or 25-50 mg/kg daily by continuous infusion.
Renal impairment: dosage reduction may be required.

Adverse drug reactions: diarrhea, nausea, vomiting, disturbances in color vision, giddiness, hypotension (after rapid IV inj), thromboembolic events.

See references for more information.

Adapted from CIMS Drug Information System. Internet. Aminocaproic acid. Tranexamic acid. Accessed on September 29, 2016.