Adult
Dosage is based on amoxicillin base.
PO
Susceptible infections — respiratory tract infections, infected animal bites, melioidosis: 250-500 mg 8 hrly or 500-875 mg 12 hrly.
Dental abscesses: 3 g as a single dose, repeated once after 8 hr.
Acute uncomplicated UTI: 3 g as a single dose, repeated once after 10-12 hr.
Severe or recurrent resp tract infections: 3 g bid.
Prophylaxis of endocarditis: 2 or 3 g as a single dose to be taken 1 hr before dental procedure.
Tonsillitis, pharyngitis — extended-release preparation: 775 mg daily for 10 days.
Eradication of H. Pylori associated w/ peptic ulcer disease: 750 mg or 1,000 mg bid, or 500 mg tid. To be taken w/ metronidazole, clarithromycin or a PPI.

IV
Susceptible infections 500 mg 8 hrly by slow inj over 3-4 min. In severe infections, may increase to 1 g 6 hrly by slow inj over 3-4 min or infusion over 30-60 min.
Prophylaxis of surgical infections 1,000 mg up to 30 min before the procedure. For high-risk procedures, up to 2-3 further doses may be given 8 hrly.

Adverse drug reactions: diarrhea/loose stools, clostridium difficile-associated diarrhea, pseudomembranous colitis, nausea, vomiting, skin rashes, urticaria, vaginitis, anaphylaxis.

See reference for details.

CIMS Drug Information System. Internet. Accessed on January 10, 2016.