5-HT3 antagonists, commonly referred to as "setrons", are primarily used for the prevention and treatment of chemotherapy-induced nausea and vomiting, particularly that associated with highly emetogenic agents such as cisplatin. For optimal efficacy, they are often administered in combination with a glucocorticoid, typically dexamethasone.

These agents are usually given intravenously shortly before chemotherapy, although some studies suggest that oral administration may be preferable in certain cases. When combined with a neurokinin-1 receptor antagonist - such as aprepitant - the effectiveness of 5-HT3 antagonists in preventing both acute and delayed nausea and vomiting is significantly enhanced.

In addition to their use in chemotherapy, 5-HT3 antagonists are also effective for the prevention and treatment of radiation-induced and postoperative nausea and vomiting. However, current evidence indicates that they are not effective in preventing or treating motion sickness.

Available agents.
- Ondansetron
- Tropisetron
- Granisetron
- Dolasetron
- Palonosetron
- Ramosetron

See reference for more information.

Adapted from Wikipedia, the free encyclopedia. Internet. Accessed on October 25, 2020.