Whipple’s procedure or Whipple’s resection is a major surgical operation involving the removal of the head of the pancreas, the duodenum, the proximal jejunum, gallbladder, and part of the stomach.
This operation is most often performed to remove cancerous or pre-cancerous tumours of the head of the pancreas or one of the related structures (Ampulla of Vater, duodenum or bile duct). Less commonly, it may be used for the management of pancreatic or duodenal trauma, or chronic pancreatitis.
This procedure was originally described by the Italian surgeon, Alessandro Codivilla, in 1898. The American surgeon, Allen Whipple, devised an improved method in 1935.