Migraine prophylaxis. Initial: 250 mg bid. Max: 1 g/day; extended release 500 mg once daily for 7 days, increased to 1 g once daily. Usual dose: 500-1000 mg/day.
Acute manic episodes of bipolar disorder - valproate semisodium: Initial: 750 mg/day in divided doses, increase as needed based on response. Max: 60 mg/kg/day.
Complex partial seizures - valproic acid or valproate semisodium: ≥10 yr Initial: 10-15 mg/kg/day in 2-4 divided doses, increase if needed. Max: 60 mg/kg/day. Na valproate: 600 mg/day in 2 divided doses, increase if needed. Usual: 1-2 g/day. Max: 2.5 g/day.
Simple and complex absence seizures. As monotherapy, conversion to monotherapy or adjunctive therapy - valproic acid or valproate semisodium: ≥10 yr Initial: 15 mg/kg/day in 2-4 divided doses, increase if needed. Max: 60 mg/kg/day.
Bipolar disorder - valpromide: 0.6-1.8 g/day in 2 divided doses. Usual: 1.2 g/day. May increase slowly to reach optimal dose w/ simultaneous and progressive dose reduction of concurrent psychotropic drugs.
Complex partial seizures, simple and complex absence seizures As monotherapy, conversion to monotherapy or adjunctive therapy - Na valproate: Initial: 10-15 mg/kg/day, increase slowly until control is achieved. Usual: 20-30 mg/kg/day. Daily doses to be given in 2-4 divided doses. Max: 60 mg/kg/day.
Adverse drug reactions
: headache, nausea, vomiting, diarrhoea, anorexia, increased appetite, somnolence, dizziness, fatigue, hyperammonaemic encephalopathy, hypothermia, hallucinations.
Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.