The hydrochloride salt of trifluoperazine, a phenothiazine derivative and a dopamine, alpha-adrenergic, and anticholinergic antagonist with antipsychotic, anxiolytic, and antiemetic activities.
Trifluoperazine blocks central dopamine receptors, which may prevent or mitigate delusions and hallucinations caused by an excess of dopamine; dopamine blockade in the chemoreceptor trigger zone (CTZ) may result in an antiemetic effect. This agent binds to central adrenergic receptors, which may result in anxiolytic effects.Trifluoperazine also functions as a calmodulin inhibitor, elevating cytosolic calcium.
Psychoses: 2-5 mg twice daily, up to 15-20 mg/day. Severe or resistant: 40 mg/day.
Nausea and vomiting; short-term management of anxiety: 1-2 mg twice daily. Max: 6 mg/day. For anxiety: max duration: 12 wk.
Acute psychosis: 1-2 mg,repeat 4-6 hrly if needed. Max: 6 mg/day