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Acid sensing ion channels

  1. After tissue damage, there is accumulation of hydrogen ions. These protons may activate nociceptors via acid sensing ion channels - a family of sodium channels on cell membranes that have a role in pain transmission.
    Of special interest is one type found only in small dorsal root ganglion neurons that are responsible for activation of nociceptors.

    Reference: Suzuki R, Sikandar S, Dickenson AH. Nociception: basic principles. In: Bruera ED, Portenoy RK (eds) Cancer Pain Assessment and Management. Cambridge University Press . Cambridge 2010, P 6.