Depression, obsessive-compulsive disorder. Initial: 50 mg/day, may increase in increments of 50 mg at wkly intervals. Max: 200 mg/day.
Panic disorder, posttraumatic stress disorder, social anxiety disorder. Initial: 25 mg/day, increased to 50 mg/day after a wk. May increase in increments of 50 mg at wkly intervals. Max: 200 mg/day.
Premenstrual dysphoric disorder. Initial: 50 mg/day. May increase in increments of 50 mg per menstrual cycle. Max: 150 mg/day (for continuous dosing) or 100 mg/day (during luteal phase). Patient who require 100 mg/day during luteal phase-only: Initial: 50 mg/day for the first 3 days of each luteal phase period.
Adverse drug reactions
: hepatitis, liver failure, jaundice, pancreatitis, stomatitis, palpitation, HTN, hypercholesterolaemia, DM, tachycardia, bronchospasm, postural hypotension, amnesia, paraesthesia, aggression, urinary incontinence, tinnitus.
Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.