Initially, 5 mg 4-6 hrly may increase as necessary. Extended-release tab: 5-10 mg 12 hrly. Max: 400 mg/day.
Injection: 1-10 mg over 1-2 min, repeated not more often than 4 hrly.
Infusion. Initial: 2 mg/hr, increased as necessary. Patient-controlled analgesia (PCA): 0.03 mg/kg, admin w/ a minimum lock-out time of 5 min.
Injection. Initial: 5 mg 4 hrly.
Infusion. Initial: 7.5 mg/day adjusted according to response.
Adverse drug reactions
: nausea, constipation, vomiting, respiratory depression, headache, pruritus, insomnia, dizziness, asthenia, somnolence, abdominal pain, chills and fever, hypotension, anorexia, diarrhoea, dyspepsia, dysphagia, anxiety, nervousness, tremor, vasodilation, cough, dyspnoea, rash.
See also Instructions and conversion table
and Opioid dose conversion
Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.