Schizophrenia. Initial: 10 mg/day as a single dose. Adjust dose according to response at intervals of not less than 24 hr to w/in the range of 5-20 mg/day.
Acute mixed or manic episodes in bipolar disorder. Initial: 10 or 15 mg/day as monotherapy or 10 mg/day as part of combination therapy. Adjust dose in increments or decrements of 5 mg at intervals of not less than 24 hr to a dose of 5-20 mg/day.
Rapid control of agitation and disturbed behaviour in schizophrenia or mania. Initial: 5-10 mg followed by 5-10 mg as required 2 hr later. Max: 20 mg/day (combined oral and parenteral dose). Patients could only receive up to 3 injection in any 24-hr period. Max duration: 3 days, but should transfer to oral therapy as soon as possible.
Adverse drug reactions
: somnolence, weight gain, increased appetite, dizziness, fatigue, elevated plasma glucose, triglyceride and liver enzyme values, oedema, orthostatic hypotension, constipation, dry mouth, leucopenia, hypercholesterolaemia, bradycardia, arthralgia, sedation.
Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.