A synthetic cannabinoid and dibenzopyrane derivative with anti-emetic activity.
Although the mechanism of action has not been fully elucidated yet, it has been suggested that nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1 and CB2, both of which are coupled to Gi/o proteins.
The CB1 receptors are expressed predominantly in central and peripheral neurons and receptor stimulation has been implicated in the reduction of chemotherapy-induced nausea.
Nabilone is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It mimics tetrahydrocannabinol (THC), the primary psychoactive compound found naturally occurring in Cannabis.
It is widely used as an adjunct therapy for chronic pain management; numerous trials and case studies have demonstrated modest effectiveness for relieving fibromyalgia and multiple sclerosis.
1 or 2 mg doses multiple times a day up to a total of 6 mg.