Ipratropium bromide causes bronchodilation by blocking the action of acetylcholine at parasympathetic site in bronchial smooth muscle. It also inhibits serous and seromucous gland secretions by nasal application.

Adult
Inhalation
COPD, asthma - metered-dose aerosol: 20-40 mcg 3-4 times/day; single doses of up to 80 mcg may be required in some patients. As soln for nebulisation: 250-500 mcg 3-4 times/day.

Nasal
Rhinorrhea associated w/ rhinitis - metered-dose nasal spray: 42 mcg into each nostril 2-3 times/day, up to 84 mcg into each nostril 3-4 times/day for up to 4 days when rhinorrhea is associated w/ common cold or up to 3 wk when associated w/ seasonal allergic rhinitis.

Adverse drug reactions: dry mouth, constipation, arrhythmias, nausea and vomiting, headaches, dizziness, mydriasis, narrow-angle glaucoma.

Adapted from CIMS Drug Information System. Internet. Accessed on January 10, 2016.