Ichthyosis appearing during adult life has a strong association with malignancy, particularly Hodgkin's disease.
The entire skin is dry with the trunk and limbs most affected. The skin has a fish-scale appearance being divided into rhomboidal areas by crisscrossing transverse lines. The palms and soles may be hyperkeratotic.
Treatment is with emollients to keep the skin as moist as possible; if scaling is severe, a keratolytic such as 2% salicylic acid can be added to the emollient.
Woodruff R. Palliative medicine evidence-based symptomatic and supportive care for patients with advanced cancer. 4th ed. Oxford University Press, 2004. p. 350.