What is Esomeprazole magnesium - Meaning and definition

Published by Roberto Wenk. Last updated date: June 14, 2016.

The magnesium salt of esomeprazole, the S-isomer of omeprazole, with gastric proton pump inhibitor activity.
In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulphenamide; the active sulphenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.

National Cancer Institute. NCI Drug Dictionary. Internet. September 15, 2009.

Published by Roberto Wenk. Reviewed by Alison Ramsey. Last updated date: November 20, 2018.

Adult
PO
Erosive oesophagitis: 40 mg once daily for 4 wk, up to another 4 wk if needed. Maintenance: 20 mg once daily.
GERD: 40 mg once daily for 4 wk, up to another 4 wk if needed. Maintenance or GERD w/o erosive oesophagitis: 20 mg once daily.
Peptic ulcer: 20 mg bid for 7 days or 40 mg once daily for 10 days as triple therapy w/ amoxicillin and clarithromycin.
Prophylaxis of NSAID-induced ulcers: 20 or 40 mg/day.
NSAID-associated ulceration: 20 mg once daily for 4-8 wk.
Zollinger-Ellison syndrome. Initial: 40 mg bid. Usual range: 80-160 mg/day. Daily doses >80 mg should be given in 2 divided doses.

IV
GERD: 20 or 40 mg by inj over at least 3 min or infusion over 10-30 min once daily for ≤10 days until PO can be resumed.
NSAID-associated ulceration. 20 mg/day by inj over at least 3 min or infusion over 10-30 min until PO can be resumed.
Gastric and duodenal ulcers: 80 mg infusion over 30 min followed by continuous infusion 8 mg/hr over 72 hr, until PO can be resumed given as 40 mg once daily for 4 wk.

Adverse drug reactions: increased risk of Clostridium difficile-associated diarrhea and osteoporosis-related fracture. Headache, rash, pruritus, dizziness, fatigue, cough, back or abdominal pain, arthralgia and myalgia, urticaria, fever, angioedema, bronchospasm, somnolence, insomnia, reversible confusional states, depression, agitation, hallucination. Increased liver enzyme, hepatitis, jaundice, hepatic encephalopathy.

CIMS Drug Information System. Internet. Accessed on January 10, 2016.

Esomeprazole magnesium

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