Erosive oesophagitis: 40 mg once daily for 4 wk, up to another 4 wk if needed. Maintenance: 20 mg once daily.
GERD: 40 mg once daily for 4 wk, up to another 4 wk if needed. Maintenance or GERD w/o erosive oesophagitis: 20 mg once daily.
Peptic ulcer: 20 mg bid for 7 days or 40 mg once daily for 10 days as triple therapy w/ amoxicillin and clarithromycin.
Prophylaxis of NSAID-induced ulcers: 20 or 40 mg/day.
NSAID-associated ulceration: 20 mg once daily for 4-8 wk.
Zollinger-Ellison syndrome. Initial: 40 mg bid. Usual range: 80-160 mg/day. Daily doses >80 mg should be given in 2 divided doses.
GERD: 20 or 40 mg by inj over at least 3 min or infusion over 10-30 min once daily for ≤10 days until PO can be resumed.
NSAID-associated ulceration. 20 mg/day by inj over at least 3 min or infusion over 10-30 min until PO can be resumed.
Gastric and duodenal ulcers: 80 mg infusion over 30 min followed by continuous infusion 8 mg/hr over 72 hr, until PO can be resumed given as 40 mg once daily for 4 wk.
Adverse drug reaction
s: increased risk of Clostridium difficile-associated diarrhoea and osteoporosis-related fracture. Headache, rash, pruritus, dizziness, fatigue, cough, back or abdominal pain, arthralgia and myalgia, urticaria, fever, angioedema, bronchospasm, somnolence, insomnia, reversible confusional states, depression, agitation, hallucination. Increased liver enzyme, hepatitis, jaundice, hepatic encephalopathy.
CIMS Drug Information System. Internet. Accessed on January 10, 2016.