Diamorphine (diacetylmorphine, heroin) is a strong opioid agonist available for medical use in the United Kingdom.
The analgesic efficacy and adverse effects of oral diamorphine and morphine were equivalent in a randomized controlled trial.
Diamorphine is considerably more soluble than morphine, facilitating the delivery of higher doses by subcutaneous infusion.
: active PO, PR, SC, IM, IV, IN, spinal and topical. Metabolized to 6-acetylmorphine and morphine. Plasma half-life: several minutes. Dduration of action: 3-4h
: moderate and severe pain
: severe hepatic or renal dysfunction, other causes of severe respiratory impairment or other causes of CNS depression
: similar to morphine
: 4-5 mg IM is equivalent to morphine 10 mg IM; 20 mg PO is equivalent to morphine 30 mg PO
: tablet, liquid, injection
Heroin is used as a recreational drug for its euphoric effects. Frequent and regular administration is associated with tolerance and physical dependence.
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